Researchers employ stable isotope techniques to study a wide variety of metabolic disorders and diseases including Alzheimer’s, Parkinson’s, cancer, diabetes, and obesity. Isotopes are most commonly used in metabolism research as tracers to quantify biochemical or metabolic reactions in vivo. They can be used to study metabolic pathways, to determine biomarkers, to test the effects of a drug, and to develop metabolic profiles of biological systems in a particular state. Please contact us if you have any questions or wish to discuss a project.
These are our metabolic catalogues containing all our metabolic products. Below this we have listed some FAQs and some helpful specific application notes written by our customers that might be of use to you….and are just generally interesting reads.
CIL provides additional testing to many of our products as a service to our customers. The following documents describe the nature of these products, the different levels of control applied to them, and the Enhanced Technical Data Package that is available for some products. Please read these documents as the choice of material grade is often crucial to the successful undertaking of a study or grant application. If you are planning to use stable isotope products for clinical research then this is especially important as we will coordinate with pharmacy/QC to make sure your raw material will be accepted.
- Analysis of Whole-Body Branched-Chain Amino Acid Metabolism in Mice Utilising 20% Leucine 13C6and 20% Valine 13C5Mouse Feed.
- The Impact of Stable Isotope Tracers on Metabolic Research
- Cellular Metabolism and Metabolomics
- Stable Isotopes in Drug Development and Personalised Medicine
- Protein Turnover
- Determining Protein Turnover in Fish D7 Leucine (Application Note 29)
- Determination of Nitric Oxide Production and de novoArginine Production with Stable Isotopes (Application Note 30)
- Tracing Lipid Disposition in vivo Using Stable Isotope-Labeled Fatty Acids and Mass Spectrometry (Application Note 31)
- Metabolic Incorporation of Stable Isotope Labels into Glycans (Application Note 23)
- Utility of Stable Isotopes in Mass Spectrometry
- Metabolic Isotopic Analysis Reveals Mitochondrial Loss of Function in pRb-Deficient Cells in vivo(Application Note 45)
- 13C Enriched Substrates for Hyperpolarisation
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